Association between Preoperative Neutrophil to Lymphocyte Ratio and Pelvic Lymph Node Metastasis in Early Stage Cervical Cancer
Watinee Wipoopinyo MD1, Sunamchok Srijaipracharoen MD1
Affiliation : 1 Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
Objective : To assess the association of pre-operative neutrophil to lymphocyte ratio [NLR] with pelvic lymph node [LN]
metastasis and other clinical features including, stage, progression-free survival [PFS], and overall survival [OS] in early stage
cervical cancer.
Materials and Methods : Clinical and pathological data of early stage cervical cancer patients (stage IA2 to IIA2) undergoing
radical hysterectomy with pelvic lymphadenectomy between January 1, 2008 and December 31, 2015 were collected and
analyzed.
Results : Mean age of 121 patients included in the study was 45+10.32 years. After a median follow-up of 38 months (range,
6 months to 114 months), 8 had recurrences (6.6%) and 3 were dead (2.5%). The 5-year PFS and 5-year OS were 91.8% and
93.8% respectively. High NLR (>2.03) was significantly associated with higher FIGO stage (stage II) and pelvic lymph node
metastases. Only FIGO stage and adjuvant treatment, but not high NLR, were significantly associated with survivals.
Conclusion : High NLR was significantly associated with LN metastasis bot not survival in cervical cancer patients initially
treated with radical surgery.
Keywords : Early stage cervical cancer, Neutrophil to lymphocyte ratio, Pelvic node metastasis
