Clinical Outcomes of Stereotactic Body Radiation Therapy in Patients with Liver Tumor: A Single Institution Study
Thong Chotchutipan MD1, Danupon Nantajit PhD1,2, Pornwaree Trirussapanich MD1, Sunanta Rojwatkarnjana MD1, Poompis Pattaranutraporn MD1, Kanyanee Laebua MD1, Sasikarn Chamchod MD1,2
Affiliation : 1 Department of Radiation Oncology, Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand 2 Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand
Background : Hepatic cancer is a global major health threat with a relatively high mortality rate. Standard treatment of the
disease includes resection and liver transplantation.
Objective : To determine clinical outcomes of stereotactic body radiation therapy in patients with liver tumor.
Materials and Methods : Patients with primary hepatic tumors or cholangiocarcinoma of stage I to IIIB in TNM staging and
those with liver metastases were included in the study for analyses of tumor response rate, local tumor control, disease-free
survival, and overall survival after stereotactic body radiation therapy [SBRT].
Results : Among 25 tumor masses in 19 patients analyzed, the overall tumor response rate was 56% (complete response 32%;
partial response 24%). The median administered biologically effective dose in Gy10 was 100 Gy. Local tumor control rates
were 87.5% and 65.6% for two and three years, respectively. Disease-free survival was 41.2% and 15.4% for two and three
years, respectively. The overall survival of the patients was 70.75% at one year. Tumors larger than 19.46 cc or 3.3 cm in
diameter were associated with inferior tumor response rate.
Conclusion : These results suggest that SBRT might be an effective therapy in hepatic tumors given its high local tumor
control rate. The major limitation of the treatment modality remains hepatic function of the patients, which restricts doses
to the tumor.
Keywords : Stereotactic body radiation therapy, Liver tumor, Hepatoma, Clinical outcomes
