Human Papilloma Virus [HPV] and Body Mass Index [BMI] in 4,487 Thai Women under Cervical Screening Program
Usanee Chatchotikawong MD1, Nuttavut Kantathavorn MD1,2, Thaniya Sricharunrat MD5, Narongrit Sritana MSc3, Chantanee Taepisitpong MNS1, Siriporn Saeloo BNS4, Waraphorn Krongthong MSc4, Narongchai Teerayathanakul MD5, Wasanai Krisorakun MD1, Manassavee Srisuttayasathien MD1
Affiliation : 1 Gynecologic Oncology Division and Woman Health Centre, Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand 2 Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand. 3 Molecular Biology and Genomic Research Laboratory, Division of Research and International Relations, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Thailand 4 Data Management Unit, Division of Research and International Relations, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand 5 Department of Pathology, Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand
Objective : To investigate body mass index [BMI] and frequency of human papilloma virus [HPV] infection and determine
their association in a Thai woman cohort.
Materials and Methods: Retrospective BMI and HPV genotyping data were retrieved from 4,487 Thai women who
participated in a cervical cancer screening program at Chulabhorn Hospital. BMI (kg/m2) was categorized as less than 18.5
(below normal weight), 18.5 to 22.99 (normal weight), 23.00 to 24.99 (upper range of normal weight), 25.00 to 29.99
(overweight), and greater than or equal to 30.00 (obese), respectively. Linear array HPV testing kit was used to identify 37
HPV types including 12 high-risk [HR], 8 probable high-risk [PR], and 17 low-risk [LR] types.
Results : Of 4,487 participants, 1,078 cases were overweight (24%), 351 cases were obese (7.8%), 801 cases (17.9%) were
in the upper range of normal weight, and 1,982 cases (44.2%) were normal. The mean BMI was 23.7 kg/m2, range 13.8 to 49
kg/m2, and 15.1%, 6.4%, 3.5%, and 8.4% of the cohort were found to have HPV infection, HR HPV, PR HPV, and LR HPV,
respectively. The BMI 25.00 to 29.99 kg/m2 (overweight) cohort had a statistically significantly lower OR of 0.66 (95% CI
0.47 to 0.93) for HR HPV infection compared with the normal BMI 18.50 to 22.99 kg/m2 cohort.
Conclusion : About half of the Thai women in this cohort had BMI in the upper range of normal to overweight and obese
criteria. Overweight women had a lower rate of HR HPV infection than women with a normal weight.
Keywords : HPV, BMI, overweight, infection, protective factor
