The Relationship between Rate-Pressure Product and Coronary Artery Stenosis in Patients with Positive Exercise Stress Test
Surapun Pongsuthana MD*, Chuntisa Arayangkoon MD*
Affiliation : * Division of Cardiology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand
Background : Coronary artery disease (CAD) is known to be a leading cause of death. Although many studies have revealed
a relationship between rate-pressure product and significant coronary artery stenosis in patients with a positive exercise
stress test, there have been few studies on the subject in Thailand. Rate-pressure product results were reviewed of exercise
stress tests performed at a single center in Thailand.
Objective : To determine a relationship between rate-pressure product and significant coronary artery stenosis in patients
with positive exercise stress test.
Material and Method: A retrospective cross-sectional study was performed by collecting medical records of patients who
had a positive exercise stress test confirmed by cardiac catheterization in Rajavithi Hospital between 1 January 2009 and 31
December 2014.
Results : A total of 126 patients were enrolled. Eighty-six patients (68.3%) were male, the mean age was 58.09+8.67 years and
the mean body mass index was 25.60+3.55 kg/m2. Although the study found that patients in the group with rate-pressure
product >30,000 bpm⋅mmHg had more non-significant coronary artery stenosis (35.3%) than those in the group with rate-
pressure product <30,000 bpm⋅mmHg (20.02%), the differences were not statistically significant (p-value = 0.163). The
group without significant coronary artery stenosis had a higher mean rate-pressure product (27,370.75+5,190.89 bpm⋅mmHg)
than the group with significant coronary artery stenosis (22,605.50+5,588.57 bpm⋅mmHg) (p-value <0.001).
Conclusion : A high rate-pressure product (>30,000 bpm⋅mmHg) is not associated with coronary artery stenosis in patients
with positive exercise stress test. Patients without significant coronary artery stenosis had a higher average rate-pressure
product.
Keywords : Rate-pressure product, Double product, Coronary artery stenosis, Cardiac catheterization, Exercise stress test
