Relationship between Hepatic Steatosis and Outcome of Viral Hepatitis C Treatment
Keerati Akarapatima, MD1, Tatsanai Sattayaraksa, MD2, Arunchai Chang, MD1, Attapon Rattanasupar, MD1
Affiliation : 1 Division of Gastroenterology, Department of Internal Medicine, Hatyai Hospital, Songkhla, Thailand 2 Department of Internal Medicine, Hatyai Hospital, Songkhla, Thailand
Background : Hepatitis C virus (HCV) infection is an important cause of liver disease. The correlation between hepatic steatosis and
HCV treatment results is unclear. Majority of studies showed that hepatic steatosis decreases efficacy of treatment while some
showed no correlation. Noninvasive modalities (transient elastrography; TE) have recently largely supplanted liver biopsy, which
may limit recognition of steatosis. The controlled attenuation parameter (CAP) from TE is a parameter to identify hepatic steatosis.
Objective : To determine the correlation between hepatic steatosis and sustained virological response (SVR).
Materials and Methods : The retrospective study analyzed data from HCV infected patients in the hepatitis clinic of Hatyai Hospital
between 2014 and 2017. All patients were measured for CAP before treatment. The correlation between hepatic steatosis and SVR
was analyzed.
Results : Seventy four HCV infected patients participated in the present study. Twenty five percent of participants were hepatic
steatosis (n = 15). SVR was 80% in hepatic steatosis group and 71.2% in group without hepatic steatosis (p = 0.50). Other factors
showed no significant except significant fibrosis.
Conclusion : There was no relationship between hepatic steatosis and HCV treatment outcome.
DOI: 10.35755/jmedassocthai.2020.S08.11988
Keywords : Controlled attenuation parameter, CAP, Hepatic steatosis, Outcome, Viral hepatitis C, Treatment
