Comparison of Efficacy between Triamcinolone and Mixture of Lidocaine-triamcinolone on Keloid Volume Reduction: A Randomized, Double Blinded, Prospective Study
Taweepraditpol S, MD1, Udkhamtiang W, MD1
Affiliation : 1 Plastic and Reconstructive Surgery Unit, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background : Triamcinolone acetonide intralesional injections have been well established in keloid treatment. Lidocaine has usually
been mixed with triamcinolone to reduce pain during the injection. Previous in vitro studies showed that lidocaine could inhibit the
fibroblast proliferation. The authors would like to study the efficacy of lidocaine-triamcinolone mixture on keloid volume reduction.
Materials and Methods : Between October 2017 and February 2018, a total 15 patients were enrolled in this study and randomly
divided into 3 groups: Triamcinolone (group A), Lidocaine mixed triamcinolone (group B), and Lidocaine with adrenaline mixed
triamcinolone (group C). All patients received the treatment a total of 4 times, once every 4 weeks. Then 4 weeks after the last
treatment, patients were evaluated for volume reduction using the Vancouver scar scale and Visual analogue score.
Results : No significant volume reduction was observed among the 3 groups (group A: 0.34+0.52 ml, group B: 0.41+0.43 ml, and
group C: 0.53+0.93 ml, p-value = 0.65). The percentage of volume reduction in group B was noticeable (group A; 47.95%, group B;
62.1%, and group C; 42.07%, p-value = 0.521). All patients in group B showed improvement in scar pliability.
Conclusion : Lidocaine-triamcinolone mixture may have higher efficacy than triamcinolone alone in term of keloid volume reduction
and scar pliability.
Keywords : Intralesional steroid injection, Lidocaine, Keloid treatment
