Seroprevalence of Measles, Mumps and Rubella Antibodies in Thai University Hospital Healthcare Workers
Tangsathapornpong A, MD1, Kaewngern T, MD1, Sajak S, RN2, Bunjongmanee P, MD1
Affiliation : 1 Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, Thailand 2 Infection Control Unit, Thammasat University Hospital, Pathumthani, Thailand
Background : Measles, mumps, and rubella are highly contagious respiratory viruses. Healthcare workers (HCWs) are at high risk
for infection and transmission to other HCWs and patients.
Objective : To study the seroprevalence of measles, mumps, and rubella antibodies in HCWs at Thammasat University Hospital,
Thailand.
Materials and Methods : This was a descriptive, cross-sectional study in 2017. IgG specific antibodies were measured in serum
samples from HCWs: measles and mumps were assessed with an enzyme-linked immunosorbent assay kit, rubella using
chemiluminescent microparticle immunoassay.
Results : One hundred and forty HCWs participated: 21 doctors (15%), 73 nurses (52.14%) and 46 other employees (32.86%). The
mean age was 29.2+6.36 years: range 20 to 57 years. The prevalence of immunity against measles was 129 (92.14%), rubella 126
(90%) and mumps 82 (58%). Older HCWs had significantly greater seroprevalence for measles (p = 0.002) and mumps (p = 0.033).
Previous measles/measles-containing vaccines history had no statistical correlation with immunological status; 10/74 HCWs
(13.51%) <29 years of age who had received 2 doses of measles/measles-containing vaccines in line with the EPI (Expanded Program
on Immunization) and no later boosters showed no measles immunity.
Conclusion : Mumps antibody seroprevalence was lower than that of measles and rubella. HCWs without immunity to measles and
mumps were found in the younger cohort. Despite having previous measles/measles-containing vaccines, HCWs should receive a
booster before employment.
Keywords : Antibody, Measles, Rubella, Mumps, Healthcare workers
