Characteristics and Outcomes of Non-occupational Post-exposure Prophylaxis in a Thai Tertiary-care Hospital
Anantachaiwanich P1, Ariyathugun P1, Amphaiphan I1, Khawcharoenporn T, MD, MSc2
Affiliation : 1 Medical Student, Faculty of Medicine, Thammasat University, Pathumthani, Thailand 2 Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
Objective : To determine characteristic and outcomes of non-occupational post-exposure prophylaxis (nPEP) in a Thai tertiary-
care center.
Materials and Methods: A retrospective cohort study was conducted among persons with non-occupational HIV exposures
presented at Thammasat University Hospital between 1 December 2014 and 31 December 2016.
Results : There were 115 individuals included; 108 (94%) were females and the median age was 18 years (IQR 14 to 23 years). Most
common reported risks included being raped (64%) and no condom use for vaginal sex (52%). nPEP antiretroviral drugs were
prescribed in 69 cases (60%). Only 15 of the 69 cases (22%) can be evaluated for completion of nPEP regimen at 28 days. All of the
15 cases were 100% compliant to nPEP and none had HIV seroconversion. Of the 115 individuals, only 6 (5%) came for follow-up
at 1 and 3 months. Independent factors associated with no follow-up were no receipt of nPEP drugs (p<0.001), female sex (p<0.001)
and older age (p = 0.004).
Conclusion : Most of the individuals at-risk for non-occupational HIV exposure were young people and the most common risk was
being raped. Strategies to improve rates of follow-up are needed to ensure the efficacy and safety of nPEP and further HIV transmission
prevention.
Keywords : Non-occupational post exposure prophylaxis, Characteristics, Outcomes, A tertiary-care hospital, Thailand
