What Factors Impact Stone-Free Rate after Retrograde Intrarenal Surgery for Large Renal Calculi?
Woranisarakul V, MD1, Lohasammakul S, MD1, Nualyong C, MD1, Taweemonkongsap T, MD1, Jongjitaree K, MD1, Phinthusophon K, MD1, Jitpraphai S, MD1, Suk-ouichai C, MD1, Sathidmangkang S, MD1, Chotikawanich E, MD1
Affiliation : 1 Division of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Objective : To investigate the outcomes of retrograde intrarenal surgery (RIRS) for large renal calculi, and to identify factors that
influence the stone-free rate after RIRS for renal stone burden greater than 2 centimeters.
Materials and Methods : This retrospective chart review included patients who underwent RIRS for renal calculi greater than 2
centimeters in size during January 2015 to December 2016 at Siriraj Hospital Thailand’s largest national tertiary referral center.
Data were collected and compared between those having and not having residual stones greater than 2 cm in diameter.
Results : The present study included 100 eligible cases. The most common site was at lower calyces (42%). The mean stone burden
size was 31.43 mm (range: 20 to 140). The average operative time was 62 minutes (range: 20 to 150), and the mean hospital length
of stay was 2.7 days (range: 1 to 22). The most common stone composition was calcium oxalate monohydrate (37%), followed by
calcium phosphate (23%). The success rate was 84% and 94% after the 1st session and 2nd session of RIRS, respectively. The factors
that were found to predict residual stone after RIRS were stone burden greater than 35 mm in size (odds ratio [OR]: 5.86, 95%
confidence interval [CI]: 1.77 to 19.57; p = 0.004) and lower pole location (OR: 1.97, 95% CI: 1.039 to 3.742; p = 0.038). Sepsis was
found in 6 patients, all of whom were successfully treated with intravenous antibiotic, except for one mortality in an
immunocompromised patient.
Conclusion : RIRS is a promising treatment option for renal calculi with large stone burden. Large kidney stones (>2 cm) can be
treated with high success rate and low morbidity. The most significant predictors of residual calculi are stone burden more than
35 millimeters in size and lower pole location.
Keywords : Flexible ureterorenoscopy, Large renal stones, Nephrolithiasis, Retrograde intrarenal surgery, Stone-free rate
