Clinical Profiles of Thai Patients with Ocular
Myasthenia Gravis in Siriraj Hospital
Supinda Leeamornsiri MD*,**,
Niphon Chirapapaisan MD**, Wanicha Chuenkongkaew MD**
Affiliation :
* Department of Ophthalmology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
** Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Ninety-six patients with ocular myasthenia gravis (OMG) seen at Siriraj Hospital during 1994 to 2004 were
retrospectively reviewed. There were 59 female (61.5%) and 37 (38.5%) male patients with mean ages of 39.5 and 33.8 years,
respectively. Patients presented with initial symptoms of only ptosis in 46.9%, only diplopia in 13.5% and both ptosis and
diplopia in 39.6%. However, diplopia alone is uncommon in childhood OMG. Fifteen percent developed systemic symptoms
within two years of diagnosis. Thyroid function test was abnormal in 27.5% of investigated patients. Most abnormalities were
hyperthyroidism. Thymoma associated with OMG is a rare condition. Most purely OMG patients can control the disease by
pyridostigmine, prednisolone or immunosuppressive drugs.
Keywords : Ocular myasthenia gravis, Ptosis, Diplopia, Pyridostigmine, Generalized myasthenia gravis
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