Highly Recommended Dose of MK4 for Osteoporosis
Narong Bunyaratavej MD*, Nipat Kittimanon MD**, Thunchanok Jitivirai BS***, Boonsom Tongthongthip CNA***
Affiliation : * Department of Orthopaedic Surgery Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Orthopaedic Surgery Unit, Praputchinnaraj Hospital, Phitsanulok, Thailand *** Orthopaedic Follow up Unit, Siriraj Hospital, Mahidol University, Bangkok, Thailand
The recommended dose of Menatretenone is 45 mg three times a day; however, the compliant in daily practice is not convenient.This study shows the twice dose per day is inferior to the recommended dose. This study used the level of Gla protein in osteocalcin as a parameter for the comparison. The mean of three-time dose a day is 11.27 nanogram per milliliter while the mean of the other group is 6.07 nanogram per milliliter after the three-month treatment.
Keywords : Dose, Menatretenone
