Non-Diabetic Glomerular Disease in Type II DM: 10 Years Experience
Orapin Chawarnkul MD*, Kriengsak Vareesangthip MD*, Leena Ongajyooth MD*, Bunyarit Cheunsuchon MD**, Paisal Parichatikanond MD**
Affiliation : * Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background : The nature of renal damage in patients with type II diabetes remains unclear.
Objective : To analyze the renal histopathology in type II diabetes who underwent renal biopsy at Siriraj
Hospital, renal unit over 10 year period.
Material and Method: The clinical and biochemical data in 54 patients with Type II DM, atypical cases of DN,
were subjected to renal biopsy and analyzed retrospectively.
Results : Ten out of fifty-four type II diabetic patients (18.5%) were diagnosed non-diabetic nephropathy
(NDN); there were 4 patients with membranous GN, 3 patients with crescentic GN1 patient of MPGN type I, 1
patient with renal change from hypertension and 1 patient with IgMN. The most important factor that had
statistically significant was nephritis urine sediment (NDN: DN 40% vs. 4.5%), However 60% of NDN had no
nephritic urine sediment.
Conclusion : There was no strong predictor to differentiate DN from NDN by clinical or biochemical data. The
only significant finding in NDN was nephritic urine sediment.
Keywords : Diabetes mellitus type 2, Diabetic nephropathies, NDN
