Prediction of Perinatal Outcomes in Patient with Pre-eclampsia: Maternal Hyperoxygenation Test on Fetal Doppler Flow
Athita Chanthasenanont MD*, Charintip Somprasit MD*, Densak Pongrojpaw MD*
Affiliation : * Division of Maternal-Fetal- Medicine, Department of Obstetrics and Gynecology, Thammasat University, Pathumthani, Thailand
Objective : Investigate if the maternal hyperoxygenation test in pregnancy with pre-eclampsia could be used
for prediction of perinatal outcomes.
Material and Method: Fifty-four singleton pre-eclampsia pregnant women were enrolled in the present study.
Positive hyperoxygenation test was defined as an increase of the middle cerebral artery (MCA) or the ductus
venosus (DV) pulsatility index (PI), or a decrease of the uterine artery or the umbilical artery (UA) PI by at
least 20%. Results of hyperoxygenation test were analyzed for the correlation with perinatal outcomes.
Results : Fetuses with positive hyperoxygenation test of the MCA had a birth weight less than the negative
group significantly. Furthermore, there was a significantly higher rate of small for gestational age (SGA)
neonates and admission to the neonatal intensive care unit (NICU) in cases with positive test of the MCA.
Conclusion : The present study shows the correlation of positive hyperoxygenation test of the MCA and low
birth weight, SGA, and NICU admission.
Keywords : Echocardiography, Doppler, Hyperoxia, Oxygen, Pre-eclampsia, Pregnancy outcome, Ultrasono- graphy, Prenatal
