The Smoothness of Blood Pressure Control of Ramipril in Essential Hypertensive Thai Patients Evaluation by 24-Hour Ambulatory Blood Pressure Monitoring

Verawan Uchaipichat PhD*, Banhan Koanantakul MD**, Chuthamanee Suthisisang PhD***

Affiliation : * Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen ** Division of Medicine, Bhumibol Adulyadej Hospital, Bangkok *** Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok

Objective : Evaluate the efficacy of ramipril 2.5 and 5 mg once daily on the degree and homogeneity of 24-hour blood pressure reduction in essential hypertensive Thai patients. Material and Method: Nineteen male subjects, aged 30 to 60 years, with newly diagnosed essential hypertension were evaluated using the 24-hour ambulatory blood pressure (24-h ABP) measurement.
Results : Twelve subjects responded and/or normalized with ramipril once daily, where the office and 24-h ABP were decreased significantly from baseline (p < 0.01). The percentage and magnitude of 24-h SBP/DBP loads after treatment were significantly decreased from 92 + 9.7/91 + 15.9 to 67 + 23.8/65 + 27.6 (p < 0.01) and from 23 + 10.6/16 + 5.3 mmHg to 17 + 10.3/10 + 4.8 mmHg (p < 0.05). Trough to peak ratio for SBP/DBP was 0.59/0.52 (overall estimated) and 0.68 + 0.23/0.52 + 0.22 (individual estimated), while the smoothness index was 0.89/1.03.
Conclusion : Ramipril 2.5 and 5 mg once daily exerted the smooth 24-hour blood pressure reduction in essential hypertensive Thai patients.

Keywords : Hypertension, Blood pressure variability, Angiotensin converting enzyme inhibitor

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