A Clinical Study of Transdermal Contraceptive Patch in Thai Adolescence Women
Rachatapon Piyasirisilp MD*, Surasak Taneepanichskul MD*
Affiliation : * Department of Obstetric and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok
Objective : To study cycle control, compliance and safety of a transdermal contraceptive patch in adolescent
Thai women.
Material and Method: Fifty-eight healthy women were assigned to receive 3 cycles of contraceptive patch
(ethinyl estradiol 20 µg and norelgestromin 150 µg /day). All participants aged 16-20 years were invited to
participate from the family planning clinic at King Chulalongkorn Memorial Hospital. Data were collected
on adverse effects, perceived advantages and disadvantages, body weight, blood pressure, patch detachments
and compliance. Data were analyzed using mean, percentage and student’s t-test.
Results : The participants’ average age was 19.4 years, height 158.8 cm, weight 51.8 kg, BMI 20.8 Kg/m2. The
most location of patch application was the abdomen and the most adverse event was breast tenderness
(31.0%) followed by application site reaction, nausea vomiting and headache respectively. The breast symptom
was mild in severity. The participants reported decrease in dysmenorrhea and shorter duration of bleeding.
There were no significant changes in body weight and blood pressure. The improvement of their facial acne
was reported. There were no pregnancies during use and the adhesion of the contraceptive patch is excellent.
Partial patch detachment was reported in only 6.9%. No completed patch detachment was found.
Conclusion : The present study found an overall positive impression of a new transdermal contraceptive patch.
The good compliance and few side effects were demonstrated. The adhesive patch contraceptive was excellent.
Keywords : Contraceptive patch, Cycle control, Side effect
