Hemophagocytic Syndrome in Dengue Hemorrhagic Fever with Severe Multiorgan Complications
Tanomsri Srichaikul MD*, Sompone Punyagupta MD*, Termkiat Kanchanapoom MD*, Chow Chanokovat MD *, Kanchit Likittanasombat MD**, Apichai Leelasiri MD***
Affiliation : * Department of Medicine, Vichaiyut Hospital, Bangkok ** Department of Medicine, Ramathibodhi Hospital, Bangkok *** Department of Medicine, Pramongkutklao Hospital, Bangkok
A 46 year old woman who presented with severe multiorgans involvement including liver, brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syn- drome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G. The authors believe that HPCS are not infrequently seen with high mortality and recommended early diagnosis and treatment with the regimen. This is the first complete report of hemophagocytic syndrome in adult dengue hemorrhagic fever in Thailand. The literature of HPCS in DHF was reviewed and discussed.
Keywords : Hemophagocytic syndrome, Dengue hemorrhagic fever, Severe multiorgan complications
