Factors Influencing the Five-Year Recurrence of Liver Carcinoma after Surgery
Ruechuta Molek1, Putipan Chatthamarak2, Prakongboon Sungkasubun3, Nitiporn Saengtawee1, Waraphorn Krongthong4, Marisa Sombutboon5
Affiliation : 1 Inpatient Liver Cancer Unit, Chulabhorn Hospital,HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand, 2 Department of Surgery, Chulabhorn Hospital,HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand, 3 Faculty of Medical and Public Heaith, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand,4 Data Management Unit, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand, 5 Nursing Department, Chulabhorn Hospital,HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand
Background: Liver carcinoma is a leading cause of death. Most liver cancers (90%) are hepatocellular carcinoma (HCC), and 10% are cholangiocarcinoma (CCA). Although hepatectomy is the treatment of choice for early stage cancer, the 5-year recurrence rates for HCC and CCA have been reported as 73.4% and 82%, respectively.
Objective: To identify risk factors for 5-year tumor recurrence and the correlation after resection of liver carcinoma.
Materials and Methods: The frequency of recurrence and corresponding risk factors were investigated in patients with HCC and CCA. Data were analyzed using Fisher’s exact test and Cox proportion-hazards model.
Results: The present study included 33 HCC and 43 CCA patients (22:11 and 25:18 male:female, 58.0±12.8 and 56.8±8.0 years, respectively). The tumor recurrence rate was 17 (51.5%) and 24 (55.8%) in HCC and CCA patients, respectively.
Conclusion: Vascular invasion was a substantial risk factor for tumor recurrence after complete resection in patients with HCC, whereas serum CA19-9 and vascular invasion were the meaningful risk factors of CCA.
doi.org/10.35755/jmedassocthai.2021.S02.12570
Keywords : Hepatocellular carcinoma, Cholangiocarcinoma, Recurrence
