Prevalence of High-grade Cervical Lesion (CIN 2+) in Women with Low Grade Squamous Intraepithelial Lesion Cytology
Asama Vanichtantikul1, Nuttavut Kantathavorn1,2, Amanda Pena3, Wasanai Krisorakun1, Thanita Wetcho1, Thaniya Sricharunrat4, Narongchai Teerayathanakul4, Taksa Luasiripanthu4, Siriporn Saeloo5, Waraphorn Krongthong5
Affiliation : 1 Gynecologic Oncology Division, Woman Health Center, Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand,2 Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand, 3 Renaissance School of Medicine at Stony Brook University, New York, USA, 4 Pathology Division, Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand, 5 Data Management Unit, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand
Background: The frequency of high-grade cervical intraepithelial neoplasia (CIN2+) among Thai women with abnormal cytology, including low-grade squamous intraepithelial lesion (LSIL), was previously reported as higher than in Western populations. The aim of this study was to evaluate the prevalence of underlying significant cervical lesions (CIN2+) in women with LSIL cytology.
Materials and Methods: A cross-sectional study was conducted among Thai women who participated in a screening program at the women’s health clinic at Chulabhorn Hospital, Thailand, between July 2011 and August 2013. A total of 63 women with LSIL cytology were recruited for colposcopic evaluations.
Results: A total of 63 women with LSIL smear were included; the median age was 38 years (22 to 67 years). Most women were multiparous (61.9%) and premenopausal (80.9%). After colposcopic evaluations, the histological results were as follows: 7 (11.1%) cases with CIN2, CIN3 or adenocarcinoma in situ; 18 (28.6%) with CIN1; 32 (66.7%) with no epithelial lesion; and no cases with cervical cancer. No clinical factors were found to correlate with high-grade cervical lesions.
Conclusion: The rates of high-grade cervical lesion (CIN2+) at initial colposcopy following LSIL cytology in our population were lower than reported in previous studies.
doi.org/10.35755/jmedassocthai.2021.S02.12565
Keywords : Prevalence, Cervical intraepithelial neoplasia (CIN), Low-grade squamous intraepithelial lesion (LSIL), Thailand
