Evaluating the Effect of Volten VR4® Kaempferia
parviflora Extracts on Blood Glucose Levels in Human
Type-2 Diabetes Mellitus and Healthy Individual: A Case-
Control Study
Ahmad Sabry Mohamad PhD¹, Muhammad Noor Nordin PhD¹, Ismail Che Ani BBA², Johan Jemberang BEng³,
Reezal Ishak PhD⁴, Ahmad Najib Hasan PhD⁴, Muhammad Imran Ahmad MD, MPhil⁵,
Mohd Rahman Omar MD, Dr. Int. Med⁶, Roszymah Hamzah MD⁷
Affiliation : ¹ Medical Engineering Section, Universiti Kuala Lumpur British Malaysian Institute, Selangor, Malaysia ² Herbs Research Centre, Subang Jaya, Selangor, Malaysia ³ JJ Asia Research Centre, Shah Alam, Selangor, Malaysia ⁴ Biomedical Science Section, Universiti Kuala Lumpur Institute of Medical Science Technology, Selangor, Malaysia ⁵ Department of Pharmacology, Universiti Kuala Lumpur Royal College of Medicine Perak, Perak, Malaysia ⁶ Medical Discipline Based Department, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Negeri Sembilan, Malaysia ⁷ Haematology Department, Ampang Hospital, Selangor, Malaysia
Background: Volten VR4® capsules contain extract of Kaempferia parviflora (KP), which has been claimed to reduce blood glucose in patients
with diabetes.
Objective: To evaluate the efficacy of Volten VR4® on healthy individuals and Type-2 Diabetes Mellitus volunteers.
Materials and Methods: The extracts of 400 mg capsules of KP were consumed for five days. The fasting and blood glucose levels of 2-hour postprandial were measured at baseline and day 5. A group of 15 healthy young adults between the age of 20- and 30-years old were the control group of the present study, while 12 volunteers aged 35 to 75 years old diagnosed with Type-2 Diabetes Mellitus constituted the experimental group. Data were validated through the Willcoxon and Friedman test statistics and error distribution.
Results: It had been shown that the specificity of KP reduced blood glucose levels and has associated with the flavonoids and polymethoxyflavones components. The results showed that consuming VR4® capsules significantly reduced blood glucose, either at the state of fasting or postprandially in diabetic individual.
Conclusion: Volten VR4® Kaempferia parviflora extract is safe to be consumed at 400 mg at one time. The study also has shown that the participants are free from adverse reactions and hypoglycaemia.
Received 5 April 2021 | Revised 30 August 2021 | Accepted 30 August 2021
doi.org/10.35755/jmedassocthai.2021.10.12751
Keywords :
Kaempferia parviflora; Blood glucose; Type-2 Diabetes Mellitus; Flavonoids; Polymethoxyflavones; Hypoglycemia and heavy metal
elements
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