Daily and Weekly Iron Supplementations to Improve Iron
Status in Infants: A Randomized Controlled Trial
Nalinee Pattrakornkul MD¹, Parichaya Ngamcherdtrakul MD¹, Warawut Kriangburapa MD¹,
Siriporn Tangjaturonrasme MD², Ramorn Yampratoom MD¹
Affiliation : ¹ Department of Pediatrics, Faculty of Medicine, Burapha University, Chonburi, Thailand ² Department of Internal Medicine, Faculty of Medicine, Burapha University, Chonburi, Thailand
Background: Iron deficiency anemia screening and iron supplementation in infants aged 6 to12 months are recommended in the Guideline in
Child Health Supervision.
Objective: To evaluate the effectiveness of weekly iron supplementation compared with daily supplementation in improving the iron status in infants.
Materials and Methods: A single-blind randomized controlled trial was conducted in infants aged 6 months visiting the Well Child Clinic between May 2019 and November 2020 at Burapha University Hospital, Chonburi, Thailand. The intervention consisted of either daily or weekly iron supplementation combined with iron-rich complementary food promotion for six months. The outcomes were the differences of serum ferritin and hematological variables before and after being iron supplemented.
Results: Sixty-nine of the six-month-old healthy infants were randomized to receive either 10 mg Fe/day as the daily group or 30 mg Fe/week as the weekly group. Forty-five infants with 24 in the daily group and 21 in the weekly group completed the intervention. After the six-month period of iron supplementation, the average differences of serum ferritin in the daily and the weekly group were 10.85 (–13.19, 34.49) and –9.31 (–23.86, –2.30) ng/mL, respectively (p=0.012). The average differences of hemoglobin in the daily and the weekly group were 0.58±0.82 and 0.08±0.59 g/dL, respectively (95% CI 0.06 to 0.93; p=0.026).
Conclusion: Daily iron supplementation of 10 mg/day is more effective than 30 mg weekly iron supplementation in improving iron status and hemoglobin level in the Thai infants.
Received 17 May 2021 | Revised 6 July 2021 | Accepted 7 July 2021
doi.org/10.35755/jmedassocthai.2021.09.12978
Keywords :
Anemia; Ferritin; Infants; Iron deficiency; Iron supplementation
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