Delayed Anticoagulation Proteins Recovery in Severe
Thalassemia Diseases Compared to Malignancies in
Children after Hematopoietic Stem Cell Transplantation
Nongnuch Sirachainan MD¹, Pornchanok Iamsirirak MD¹, Samart Pakakasama MD¹, Suradej Hongeng MD¹,
Ampaiwan Chuansumrit MD¹, Praguywan Kadegasem BSc¹, Arjit Tirakanjana MD², Somtawin Sirireung BSc³
Affiliation : ¹ Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand ² Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand ³ Department of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Alterations of hemostasis have been observed following hematopoietic stem cell transplantation (HSCT). In thalassemia diseases, the evidences
of coagulation stimulation have been observed in patients with thalassemia major with and without splenectomy. The comparison between
thalassemia disease before and after HSCT, and malignancy has never been reported. The hemostasis parameters in 8 patients with thalassemia
disease and 10 patients with malignancy before, day 0, days 14, days 30, days 60, days 90, and days 180 of HSCT were studied. The median (range)
ages in thalassemia, malignancy and normal control groups were 8.5 (2 to 17), 11.0 (2.0 to 19.0) and 10.0 (0 to 16.0) years, respectively (p=0.42).
D-dimer level was significantly higher during days 14 to 60 of HSCT in both groups when compared to the normal control group. Protein C and
antithrombin activities were significantly lower during HSCT in thalassemia when compared to the malignancy and normal control groups, while,
no changes of anticoagulation proteins in malignancy group were observed.
Received 6 May 2021 | Revised 20 July 2021 | Accepted 21 July 2021
doi.org/10.35755/jmedassocthai.2021.08.12904
Keywords :
Stem cell transplantation; Hemostasis; Thalassemia diseases; Malignancy
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