Septic Shock Outcome and Factors Associated with Mortality in the Intensive Care Unit in Vietnam

Tran Nguyen Trong Phu MD¹, Do Thi Thao PhD², Vo Pham Minh Thu PhD¹, Ngo Van Truyen PhD¹

Affiliation : ¹ Department of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam ² Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam

Objective: To evaluate the mortality rate of septic shock patients and to learn about the associated risk factors for death.
Materials and Methods: Septic shock is a life-threatening subset of sepsis with profound circulatory, cellular, and metabolic abnormalities. The authors conducted an analytical cross-sectional study on adult patients diagnosed with septic shock using Sepsis-3 criteria between May 2016 and May 2018 at an intensive care unit at a hospital in Vietnam. Data on patients’ outcomes and associated factors were collected through questionnaires and the patient medical records. To measure the association between independent variables and outcomes, odds ratio (OR) and 95% confidence interval (CI) were calculated using logistic regression.
Results: One hundred fifty patients with septic shock were enrolled in the present study. Septic shock occurred in 71.3% of the 60-years-old patients and 54% were men. The mean age was 68.5±15.52 years. The mortality rate was 62% and 17.3% of patients died within 24 hours after being diagnosed with septic shock. The median length of ICU stay was four days. The initial mean SOFA and APACHE II scores were significantly higher in the death group. Septic shock patients with comorbidities had a higher mortality risk compared to those without comorbidity (OR 2.9, 95% CI 1.116 to 7.700). Patients who developed septic shock in the hospital were at greater death risk (OR 7.8, 95% CI 3.3 to 18.2). Septic shock due to pneumonia had a higher mortality risk in comparison with those due to the other causes (OR 5.2, 95% CI 2.4 to 11.0).
Conclusion: The mortality rate of patients with septic shock in Vietnam was considerably high. Many factors were identified as risks, such as nosocomial infection and respiratory tract diseases.
Received 26 June 2020 | Revised 23 April 2021 | Accepted 28 April 2021

doi.org/10.35755/jmedassocthai.2021.08.11596

Keywords : Septic shock; Outcome; Risk factors; Vietnam

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