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Reducing Pain after Second Trimester Genetic Amnio- centesis by Postprocedural Cryotherapy: A Randomized Controlled Trial

Orawee Kuemanee MD¹, Densak Pongrojpaw MD¹, Athita Chanthasenanont MD¹, Sawanya Benchahong MD¹, Junya Pattaraarchachai PhD², Kornkarn Bhamarapravatana PhD³, Komsun Suwannarurk MD¹

Affiliation : ¹ Department of obstetrics and gynecology, Faculty of medicine Thammasat University, Pathum Thani, Thailand ² Chulabhorn International College of Medicine, Thammasat hospital, Pathum Thani, Thailand ³ Department of preclinic science, Faculty of medicine, Thammasat University, Pathum Thani, Thailand


Objective: To evaluate the effectiveness of cryotherapy on pain reducing after the second trimester genetic amniocentesis.
Materials and Methods: A prospective randomized controlled trial was performed at Maternal-Fetal-Medicine (MFM) Unit at Thammasat University Hospital, Thailand between December 2019 and March 2020. The participants were pregnant women who underwent amniocentesis for genetic evaluation during the study period were divided into two groups, study and control. After finishing amniocentesis, study and control groups received jelly pack at temperature 4-degree Celsius and room temperature, respectively. The pain measurement was 10-cm visual analog scale (VAS) before, during, and 15 and 30 minutes after amniocentesis. Demographic characters and VAS score were recorded and evaluated.
Results: Two hundred forty pregnant women between 15 and 22 weeks of gestation were recruited and equally allocated into two groups. There were no differences between the two group in demographic data, indication, anticipated, and actual pain scores (p=0.327 and 0.401, respectively). Median pain score at 15 and 30 minutes after the procedure in the study group were 1 and 0 (p=0.202) while in the control group it was 2 and 1 (0.039). Patients’ satisfaction after finishing the procedure was not significantly different.
Conclusion: Cryotherapy was effective in decreasing maternal pain perception after amniocentesis.
Received 18 December 2020 | Revised 3 March 2021 | Accepted 12 March 2021

doi.org/10.35755/jmedassocthai.2021.08.12338

Keywords : Pregnancy; Amniocentesis; Cold pack; Cryotherapy; Pain


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