SAMe-TT₂R₂ Score for Prediction of Anticoagulation Control in Thai Patients with Non-Valvular Atrial Fibrillation

Apisit Leedumrongwattanakul MD¹ , ²

Affiliation : ¹ Cardiology Unit, Department of Medicine, Pranangklao Hospital, Nonthaburi, Thailand ² Faculty of Medicine, Siam University, Bangkok, Thailand

Background: The quality of anticoagulation control is an important determination of thromboembolism and bleeding in patients with non-valvular atrial fibrillation. Previous trials have shown that SAMe-TT₂R₂ score could be used for prediction of anticoagulation control.
Objective: To predict labile international normalized ratio (INR) by SAMe-TT₂R₂ score in Thai patients with non-valvular atrial fibrillation.
Materials and Methods: The author retrospectively studied patients with non-valvularatrial fibrillation at Pranangklao Hospital between January 2019 and October 2020.
Results: One hundred thirty patients were enrolled. The average ages of the patients were 67.5±10.2 years. The average SAMe-TT₂R₂ scores were 3.2±0.8 and the average CHA₂DS₂-VASc score was 3.3±1.4. Most patients had hypertension and dyslipidemia. Most patients were prescribed beta- blockers. Most patients had time in therapeutic range (TTR) lower than 65. The present study has shown that patients with SAMe-TT₂R₂ score of 3 or more has also had high proportion of labile INR with statical significance. The sensitivity, specificity, positive predictive value, and negative predictive value of different cut-offs of SAMe-TT₂R₂ score greater than 2 and SAMe-TT₂R₂ score when excluding race showed improvement of the sensitivity and specificity for prediction of labile INR.
Conclusion: Labile INR was predicted by SAMe-TT₂R₂ score and the sensitivity and specificity increased in SAMe-TT₂R₂ score when excluding race.
Received 5 February 2021 | Revised 16 April 2021 | Accepted 20 April 2021

doi.org/10.35755/jmedassocthai.2021.06.12415

Keywords : SAMe-TT₂R₂ score; Non-valvular atrial fibrillation; Anticoagulation control

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