The Comparative Study of Efficacy between Cream
Containing Spent Grain Wax, Shea Butter, Argania spinosa
Kernel Oil, Tapioca Starch, and 1% Hydrocortisone Cream
in The Treatment of Intertrigo
Apirat Rodjanont MD¹, Nanticha Kamanamool MD, PhD², Nutjira Cheyasak MD³, Chanchuree Samathi Asawutmangkul MD⁴,
Montree Udompataikul MD¹
Affiliation :
¹ Skin Center, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand ² Department of Preventive and Social Medicine, Srinakharinwirot University, Bangkok, Thailand ³ Department of Medicine, Panyananthaphikku Chonphathan Medical Center, Srinakharinwirot University, Nonthaburi, Thailand ⁴ Department of Pediatrics, Panyananthaphikku Chonphathan Medical Center, Srinakharinwirot University, Nonthaburi, Thailand
Background : Intertrigo is a common skin problem. Although there was no standard treatment due to few clinical studies, topical corticosteroids,
and drying agents such as talcum are usually used to treat intertrigo, and the side effects of these agents should be monitoring.
Objective : To compare the efficacy between cream containing spent grain wax, shea butter, Argania spinosa kernel oil, Tapioca starch, and 1% hydrocortisone cream for the treatment and prevention of intertrigo. Materials and Methods : Fifty-eight lesions from 18 intertrigo patients were randomized into two groups, HCC group, which is the 1% hydrocortisone cream and STIMU-TEX AS group, which is the combination cream of spent grain wax, shea butter, Argania spinosa kernel oil, and tapioca starch. The evaluations were performed at baseline, the first week, the second week, and the fourth week via scoring of skin redness, pruritus, excoriation, Dermatology Life Quality Index (DLQI), and patient satisfaction. The adverse events were also recorded.
Results : All participants completed the protocol. At the end of the study, 27 of 29 lesions were completely cured in the HCC group, and 25 of 29 lesions cured in the STIMU-TEX AS group. Although the number of complete remissions of the STIMU-TEX AS group was inferior to the HCC group, it was not statistically significant. There was no relapse within two weeks after completing the treatment.
Conclusion : The outcomes showed no statistically significant difference between both groups; thus, the cream may be considered as an alternative treatment and prevention of intertrigo.
Received 18 August 2020 | Revised 19 October 2020 | Accepted 20 October 2020
doi.org/10.35755/jmedassocthai.2021.04.11643
Keywords :
Intertrigo, Spent grain wax, Shea butter, Argania spinosa kernel oil, Tapioca starch
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