Acute Exercise Improves Forearm Blood Flow during
Postprandial Hyperglycemia in Normotensive Offspring
of Hypertensive Parents
Jutapakdeekul W, MSc¹, Kulaputana O, MD, PhD¹
Affiliation : ¹ Sports Medicine Program, Department of Physiology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
Background: Hyperglycemia can cause vascular impairment and exercise training improves it. It is unknown whether a single
bout of high-intensity aerobic interval exercise (HIIE) can improve vasoactive impairment induced by high blood sugar in
genetically predisposed hypertensive individuals.
Objective: To study the effects of HIIE on forearm blood flow (FBF) during postprandial hyperglycemia in healthy young men with a parental history of hypertension.
Materials and Methods: Ten normotensive young men (aged 21.3±1.4 year, BMI 21.3±2.1 kg/m²), with hypertensive parent(s), participated in two experimental conditions, oral glucose loading (OGL) without exercise and OGL with exercise, in a randomized crossover fashion on two separated visits. Glucose solution was ingested 10 minutes after treadmill exercise, which was performed for thirty-eight minutes. In both occasions, the area under curve of FBF (FBF AUC ) during reactive hyperemia using venous occlusion plethysmography was determined at baseline and thirty minutes after OGL.
Results: Differences in FBF response were found between the two conditions. FBF AUC significantly decreased from 1,240.7±266.7 ml/100 ml/5 minute at baseline to 1,069.4±152.7 ml/100 ml/5 minute (p=0.011) after OGL without exercise. As for with exercise, FBF AUC at 30 minutes after OGL tended to increase from baseline (baseline level 1,135.7±215.1 versus 1,253.3±193.7 ml/100 ml/5 minute at 30 minutes after OGL, p=0.104). The FBF AUC in response to OGL with exercise was significantly higher when compared to without exercise (p=0.001).
Conclusion: HIIE can prevent a decline of blood flow due to high blood glucose in offspring of hypertensive parent(s). Such exercise may play an important role in preventing impaired vascular function and the development or progression of atherosclerosis in healthy young men at risk of hypertension.
Keywords : High-intensity aerobic interval exercise, Forearm blood flow, Postprandial hyperglycemia, Normotensive offspring
of hypertensive parents
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