Intravenous Immunoglobulin Responsive in Two Distinct Patterns of Steroid Resistance Chronic Dysimmune Neuropathies:
Case Report:

Aungsumart S, MD, PhD¹, Apiwattanakul M, MD¹

Affiliation : ¹ Department of Neurology, Prasat Neurological Institute, Bangkok, Thailand

Chronic dysimmune neuropathies are heterogeneous immune-mediated disorders affecting peripheral nervous system. The main stay of treatment is regulation of the immune system by immunosuppressive or immunomodulatory drug. The authors described two patients with rare form of chronic dysimmune neuropathies that were multifocal acquire demyelinating sensory and motor neuropathy (MADSAM) and chronic ataxic neuropathy ophthalmoplegia IgM paraprotein cold agglutinins disialosyl antibodies (CANOMAD). Their symptoms were worsening after high dose steroid but dramatically responded to the Thai Red Cross intravenous immunoglobulin (IVIg). This data suggested effectiveness and safety of the Thai Red Cross IVIg in patients with chronic dysimmune neuropathies.

Keywords : Chronic inflammatory demyelinating polyneuropathy (CIDP), Multifocal acquire demyelinating sensory and motor neuropathy (MADSAM), Chronic ataxic neuropathy ophthalmoplegia IgM paraprotein cold agglutinins disialosyl antibodies (CANOMAD), Intravenous immunoglobulin (IVIg)

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