Maternal Bodyweight and Magnesium Sulfate Levels in
Preeclampsia
Metha Songthamwat MD¹, Sunanthaporn Phaiphan MD¹, Srisuda Songthamwat MD¹
Affiliation :
¹ Department of Obstetrics and Gynecology, Udonthani Hospital, Udonthani, Thailand
Objective : To determine the effect of maternal body weight (BW) to the serum level of Magnesium sulfate (MgSO4) in preeclampsia
and de(cid:976)ine the optimum maintenance doses in different maternal weight groups.
Materials and Methods: A cross sectional study of preeclampsia patients who were treated by MgSO4. The percentages of
subtherapeutic level of Mg in the (cid:976)irst four hours and the optimum maintenance dosage, which achieved the therapeutic level,
were compared in different BW groups.
Results : Four hundred seventy patients were included in this study. According to BW, 45.6% of the group with BW of less than 60
kg achieved therapeutic level in the (cid:976)irst four hours, compared with 23.8% of the group with BW 60 to 79.9 kg, 14.9% of the group
with BW 80 to 99.9 kg, and 0% of the group with BW of 100 kg or more (p<0.05). After adjusting the maintenance dose of MgSO4,
the optimum maintenance dosages were 1.11±0.19 g/hour in BW of less than 60 kg group, 1.28±0.34 g/hour in 60 to 79.9 kg group,
1.35±0.39 g/hour in 80 to 99.9 kg group, and 1.43±0.44 g/hour in 100 kg or more group (p<0.05).
Conclusion : The higher maternal BW causes the lower serum Mg level in preeclamptic patients who were treated with MgSO4.
From the present study, the optimum maintenance dose was suggested for each weight group. However, the effectiveness of this
protocol needs further evaluation.
Keywords : Preeclampsia, Eclampsia, Pharmacology, Labor management, Magnesium sulfate
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