Tongluk Teerasarntipan MD1, Khajohn Tiranathanagul MD, MSc2,3, Kessarin Thanapirom MD, MSc1,3, Roongruedee Chaiteerakij MD, PhD1,3, Piyawat Komolmit MD, PhD1,3, Pisit Tangkijvanich MD3,4, Sombat Treeprasertsuk MD, PhD1,3
Affiliation : 1 Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 2 Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 3 King Chulalongkorn Memorial Hospital, Thai Red Cross, Bangkok, Thailand 4 Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Objective : To validate the chronic liver failure-sequential organ failure assessment [CLIF-SOFA] tool for the diagnosis of acute-on-
chronic liver failure [ACLF] in hospitalized Thai patients with cirrhosis and to evaluate the clinical signi(cid:976)icance of urine neutrophil
gelatinase-associated lipocalin [uNGAL] in combination with the CLIF-SOFA score to predict ACLF mortality.
Materials and Methods : Seventy-seven patients were enrolled. The authors generated new ACLF diagnostic criteria by combining
the uNGAL level with the original renal failure criteria from the CLIF-SOFA score [CLIF/NGAL score]. The primary endpoint was
the 30-day mortality rate [MR].
Results : ACLF patients, according to the original CLIF-SOFA score, had a 43.7% MR in comparison to the non-ACLF patients, who
had a 13.3% MR. The calculated odds ratio [OR] was 3.28, with an area under the ROC [AUROC] of 0.750 (95% CI 0.62 to 0.88, p =
0.001). The CLIF/NGAL score demonstrated better prognostic prediction ability. The MR was 38.6%, with an OR of 4.03 (95% CI
1.29 to 12.61) and an AUROC of 0.772 (95% CI 0.65 to 0.90, p<0.001).
Conclusion : The CLIF-SOFA score is valid for ACLF diagnosis among Thai patients. Moreover, the authors new proposed criteria,
the CLIF/NGAL score, demonstrated better potential than the original criteria for ACLF mortality prediction.
Keywords : Renal failure, NGAL, Acute-on-chronic liver failure, Cirrhosis, Mortality
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