Prevalence of Left Ventricular Non-Compaction and Factors Associated with Left Ventricular Systolic Dysfunction in Patients Who Underwent Cardiac Magnetic Resonance Imaging
Suwit Khlangpremchit MD1, Rungroj Krittayaphong MD1
Affiliation : 1 Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background : Left ventricular non-compaction [LVNC] cardiomyopathy is a cause of left ventricular systolic dysfunction [LVSD].
Objective : To investigate the prevalence of LVNC, and the factors associated with LVSD in patients who underwent cardiac magnetic
resonance [CMR] imaging.
Materials and Methods : This retrospective chart and imaging review included consecutive adult patients who underwent CMR at
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand between January and March 2012. Non-compact layer
[NC] and compact layer [C] diameters were measured in each of three long-axis views. The maximum value of NC/C was used.
LVNC was diagnosed if the NC/C value was greater than 2.3. Univariate and multivariate analysis were performed to identify factors
associated with LVSD, which was de(cid:976)ined as left ventricular ejection fraction of less than 50%.
Results : Four hundred thirteen patients were included. The mean age of patients was 66.12±14.43 years, and 241 were male. The
prevalence of LVNC was 3.6% (95% CI 2.2% to 5.9%). NC/C ratio in the LVNC and non-LVNC group was 3.34±0.84 and 1.56±0.47,
respectively. Multivariate analysis revealed the (cid:976)ive factors that signi(cid:976)icantly associated with LVSD (all p<0.05), which were male,
body mass index, heart rate, hypertension, and LVNC.
Conclusion : Prevalence of LVNC was 3.63%. Factors signi(cid:976)icantly associated with LVSD were male gender, BMI, heart rate,
hypertension, and maximum NC/C greater than 2.3.
Keywords : Thailand, Prevalence, Left ventricular non-compaction, Left ventricular systolic dysfunction, Cardiac magnetic resonance imaging
