Safety and Ef(cid:976)icacy of Fermented Olive Tree Leaf Extract for
Treatment of Paronychia and Neoscytalidium dimidiatum
Onychomycosis: A Pilot Study
Sumanas Bunyaratavej MD1, Charussri Leeyaphan MD1, Pattriya Chanyachailert MD1, Chuda Rujitharanawong MD1,
Waritch Kobwanthanakun MD1, Sutasinee Phaitoonwattanakij MD1, Lalita Matthapan BSc1, Kamonpan Lertrujiwanit BSc1
Affiliation :
1 Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Objective : To evaluate the ef(cid:976)icacy and safety of Olea europaea leaf extract for treatment of chronic paronychia and Neoscytalidium
dimidiatum onychomycosis.
Materials and Methods : The present prospective pilot study was conducted. O. europaea leaf extract was applied twice a day.
Assessment parameters were evaluated at baseline, 2-, 4-, and 6-months.
Results : A total of 9 chronic paronychia patients and 9 N. dimidiatum onychomycosis patients were included. Concerning chronic
paronychia, thumb nail was common affecting site. Candida albicans revealed in 6 (66.7%). Comparing with baseline, severity of
chronic paronychia was signi(cid:976)icantly reduced within 6 months after treatment (p = 0.021). For N. dimidiatum onychomycosis, all
affected on big toenails. Mean normal nail length at baseline was 7.1 mm, which signi(cid:976)icantly improved after 6 months treatment
to 8.9 mm (p = 0.016). Nail thickness signi(cid:976)icantly reduced after 6 months treatment (p = 0.001). No adverse events were observed
in the present study.
Conclusion : O. europaea leaf extract has been shown to be an effective and safe alternative topical treatment for chronic paronychia
from Candida spp. infection and N. dimidiatum onychomycosis. No side effect was found in the present study.
ClinicalTrials.gov identi(cid:980)ier: NCT02464826
Keywords : Olive tree, Olea europaea, Chronic paronychia, Onychomycosis, Neoscytalidium dimidiatum
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