Anti-GQ1b-negative Miller Fisher Syndrome Associated with Syndrome of Inappropriate Antidiuretic Hormone: A Case Report

Pat Korathanakhun MD1, Pornchai Sathirapanya MD1, Suwanna Setthawatcharawanich MD1

Affiliation : 1 Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand

Miller Fisher syndrome [MFS] is an immune mediated polyradiculoneuropathy associated with antiganglioside antibody. The immunopathological mechanism of antiganglioside directly attack the nodal and paranodal regions of peripheral nerve. Though anti-GQ1b antibody was strongly associated with MFS, other antigangliosides and negative antibody cases were occasionally mentioned. This current study reports the clinical characteristic and non-neurological presentation of syndrome of inappropriate antidiuretic hormone [SIADH]. The possible pathophysiology of non-neurological symptoms was brie(cid:976)ly reviewed.

Keywords : Miller Fisher syndrome, SIADH, Ataxia, Ophthalmoplegia, Anti-GQ1b antibody

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