Change in Serum Chloride Level after Loading Dose of Sterofundin Solution Compared with Normal Saline Solution

Sunthiti Morakul MD1, Cherdkiat Karnjanarachata MD1, Thanist Pravitharangul MD1, Viratch Tangsujaritvijit MD2

Affiliation : 1 Department of Anesthesiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 2 Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Objective : To evaluate serum chloride level after loading dose of sterofundin solution given to healthy volunteers in the resuscitation manner compared with normal saline solution.
Materials and Methods : Ten healthy volunteers were randomly assigned to receive normal saline or sterofundin for the (cid:976)irst solution in dose of 30 mL/kg (maximum 2 liters) over one hour. After washout period of at least one week, crossover studies were performed in the same participants with another remaining solution (10 participants for each solution, total n = 20). For each solution loading, blood was collected at baseline (T0), at 60 minutes (T1), 120 minutes (T2), and 240 minutes (T4) from baseline. Time to (cid:976)irst void after initiation of (cid:976)luid and urine volume were also recorded. Primary outcome was change in serum chloride level.
Results : With sterofundin loading, delta chloride level change from baseline at T1, T2, and T4 were 2.33±1.41, 0.78±0.83, and 0.89±1.17, respectively, which were signi(cid:976)icantly lower than delta change after normal saline loading (4.2±1.03, 3.3±1.16, and 2.4±1.58, p = 0.021). The decrease in SID was lesser (p = 0.017), time to (cid:976)irst void was signi(cid:976)icantly shorter (p = 0.008), with larger but not statistically signi(cid:976)icant urine volume (p = 0.068).
Conclusion : Sterofundin solution loading slightly increased serum chloride level, but delta change from baseline was signi(cid:976)icantly lower as compared with normal saline solution.

Keywords : Chloride, Fluid, Normal saline, Osmolality, pH, Resuscitation, SID, Sterofundin, Urine

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