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Effects of Plasma Lipids and Abdominal Obesity on Heart Rate Variability in Thai Overweight Dyslipidemic Individuals at Khon Kaen, Northeast Thailand

Jatuporn Phoemsapthawee PhD*, Suphannika Ladawan PhD**, Nongnuch Settasatian PhD***, Naruemon Leelayuwat PhD****

Affiliation : * Department of Sports Science and Health, Faculty of Sports Science, Kasetsart University, Nakhon Pathom, Thailand ** School of Applied Health Sciences, University of Phayao, Phayao, Thailand *** Division of Clinical Chemistry, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand **** Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

Background : Reduced heart rate variability (HRV), a marker of autonomic imbalance, is associated with increased cardiovascular disease (CVD) risk.
Objective : To investigate dyslipidemia effects on HRV and HRV correlations with plasma lipids and adiposity measures in Thai overweight dyslipidemic individuals. Material and Method: HRV of 84 dyslipidemic subjects (age 48.7±6.7 years, BMI 25±2.3 kg/m2) were compared with 20 normolipidemic subjects (56±2.3 years, BMI 26±1.7 kg/m2). Then, HRV correlations with lipid levels and adiposity were assessed in 84 dyslipidemic subjects. HRV was determined from 10-minute continuous resting electrocardiography. Anthropometry, body composition, and plasma lipid profile, measured in blood samples after overnight fasting, were also measured.
Results : Total power (p<0.01), low-frequency power (LF) (p<0.01), high-frequency power (HF) (p<0.01), LF/HF ratio (p<0.05), standard deviation of R-R intervals (p<0.01), root mean square of successive differences (p<0.01), and percentage difference between adjacent normal R-R intervals >50 ms (p<0.01) were significantly lower in dyslipidemic than normolipidemic subjects. HF (nu) in these dyslipidemic subjects negatively correlated with triglycerides (TG), TG/high-density lipoprotein cholesterol (HDL-c) ratio, and waist-to-hip (W/H) ratio whereas, LF (nu) and LF/HF ratio positively correlated with TG, TG/HDL-c ratio, and W/H ratio.
Conclusion : Autonomic imbalance correlated with CVD risk factors in Thai overweight dyslipidemic individuals, suggesting increased CVD risk.

Keywords : Lipid profile, Autonomic imbalance, Cardiovascular disease risk


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