Effects of Plasma Lipids and Abdominal Obesity on
Heart Rate Variability in Thai Overweight Dyslipidemic
Individuals at Khon Kaen, Northeast Thailand
Jatuporn Phoemsapthawee PhD*, Suphannika Ladawan PhD**,
Nongnuch Settasatian PhD***, Naruemon Leelayuwat PhD****
Affiliation :
* Department of Sports Science and Health, Faculty of Sports Science, Kasetsart University, Nakhon Pathom, Thailand
** School of Applied Health Sciences, University of Phayao, Phayao, Thailand
*** Division of Clinical Chemistry, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
**** Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Background : Reduced heart rate variability (HRV), a marker of autonomic imbalance, is associated with increased
cardiovascular disease (CVD) risk.
Objective : To investigate dyslipidemia effects on HRV and HRV correlations with plasma lipids and adiposity measures in
Thai overweight dyslipidemic individuals.
Material and Method: HRV of 84 dyslipidemic subjects (age 48.7±6.7 years, BMI 25±2.3 kg/m2) were compared with
20 normolipidemic subjects (56±2.3 years, BMI 26±1.7 kg/m2). Then, HRV correlations with lipid levels and adiposity were
assessed in 84 dyslipidemic subjects. HRV was determined from 10-minute continuous resting electrocardiography.
Anthropometry, body composition, and plasma lipid profile, measured in blood samples after overnight fasting, were also
measured.
Results : Total power (p<0.01), low-frequency power (LF) (p<0.01), high-frequency power (HF) (p<0.01), LF/HF ratio
(p<0.05), standard deviation of R-R intervals (p<0.01), root mean square of successive differences (p<0.01), and percentage
difference between adjacent normal R-R intervals >50 ms (p<0.01) were significantly lower in dyslipidemic than
normolipidemic subjects. HF (nu) in these dyslipidemic subjects negatively correlated with triglycerides (TG), TG/high-density
lipoprotein cholesterol (HDL-c) ratio, and waist-to-hip (W/H) ratio whereas, LF (nu) and LF/HF ratio positively correlated
with TG, TG/HDL-c ratio, and W/H ratio.
Conclusion : Autonomic imbalance correlated with CVD risk factors in Thai overweight dyslipidemic individuals, suggesting
increased CVD risk.
Keywords : Lipid profile, Autonomic imbalance, Cardiovascular disease risk
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