Predictive Factors to Determine Post-Operative
Mortality in Patients with Peripheral Arterial Disease
Rungrujee Kaweewan MD*, Saritphat Orrapin MD*,
Antika Wongthanee MSc**, Kittipan Rerkasem MD, PhD*,**
Affiliation :
* NCD Center, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
** NCD Research Center, Research Institute for Health Science, Chiang Mai University, Thailand
Objective : Major vascular surgery of peripheral arterial disease (PAD) is a high post-operative mortality procedure. There
are few studies in predictive factors for post-operative mortality in Asian populations. Assessing the predictive factors
preoperatively can prolong survival in this population.
Material and Method: The prospective study included patients with PAD who had major vascular surgery between December
2002 and December 2005 at the Maharaj Nakorn Chiang Mai Hospital. Survival status and predictive factors of mortality
were analyzed.
Results : One hundred one patients were included in the present study. Fifty-three patients died (62.3%) with 4.19 years of
median survival time; 5-year survival was 47.28%. The predictive factors effecting mortality were hyponatremia (hazard
ratio (HR) 17.69, 95% confidence interval (CI) 2.02 to 154.91), respiratory distress sign (shortness of breath at rest)
(HR 12.36, 95% CI 2.12 to 71.75), atrial fibrillation (HR 3.18, 95% CI 1.39 to 7.29), abnormal plasma potassium (HR 2.80,
95% CI 1.28 to 6.15), and preoperative hypertension (HR 0.54, 95% CI 0.30 to 0.98).
Conclusion : Serum hyponatremia, shortness of breath, atrial fibrillation, abnormal plasma potassium level, and hypertension
were the predictive factors for high mortality in patients with PAD.
Keywords : Post-operative mortality, Peripheral arterial disease, Risk factor
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