Severe Deferiprone-Induced Arthropathy in Young Adolescent Successfully Treated with Intraarticular Triamcinolone Acetonide Injection: A Case Report

Jassada Buaboonnam MD*, Sirirat Charuvanij MD**

Affiliation : * Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Deferiprone (DFP), an oral chelation therapy, has improved treatment adherence and quality of life of transfusion dependent thalassemia (TDT). DFP-induced arthropathy is usually mild and self-limited; the severe DFP-induced arthropathy is uncommon presentation. Herein, a Thai girl diagnosed as TDT was initially treated with DFP. She subsequently developed severe DFP-induced bilateral knee arthritis despite discontinuing DFP and using non-steroidal anti-inflammatory drugs (NSAIDs). She was treated with arthrocentesis and intraarticular triamcinolone acetonide injection and responded well to the treatment.

Keywords : Deferiprone, Thalassemia, Arthropathy, Triamcinolone acetonide

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