Treatment of Eyebrow Hypotrichosis with 1% Minoxidil Lotion: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

Nigun Worapunpong MD*, Chuchai Tanglertsampan MD*

Affiliation : * Department of Dermatology, School of Anti-aging and Regenerative Medicine Mae Fah Luang University Hospital (Bangkok), Bangkok, Thailand

Background : Although there is no standard treatment of eyebrow hypotrichosis, many physicians have been prescribing minoxidil lotion. We demonstrated in the previous study that 2% minoxidil lotion was a safe and effective treatment for eyebrow hypotrichosis.
Objective : The aim of the present study is to determine the efficacy and safety of 1% minoxidil lotion compared to placebo for eyebrow enhancement. Material and Method: A total of 42 subjects (18-60 years old) were randomized to apply 1% minoxidil on one side of eyebrow and placebo on the other side. Efficacy and side effects were evaluated every 4 weeks for 16 weeks.
Results : Forty subjects (95%) completed this 16-week study. At week 16, 1% minoxidil was significantly superior to placebo for global photographic assessment, eyebrow diameter, eyebrow hair count, and patient’s satisfaction. There was no difference in side effects between two groups.
Conclusion : Our study showed that 1% minoxidil was a well-tolerated and effective treatment for eyebrow hypotrichosis

Keywords : eyebrow, hypotrichosis, minoxidil, placebos, therapy

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