Adverse Outcomes of Pregnancy with Single Abnormal Value of 100-Gram Oral Glucose Tolerance Test in Phramongkutklao Hospital

Thanakorn Heetchuay MD*, Peerapun Punpuckdeekoon MD*

Affiliation : * Department of Obstetrics & Gynecology, Phramongkutklao Hospital, Bangkok, Thailand

Objective : To determine the adverse outcomes of pregnancy in women with single abnormal value of the 100g OGTT compared with women with normal value of 100g OGTT. Material and Method: This retrospective study was conducted by reviewing medical records of all pregnant women screened for gestational diabetes mellitus (GDM) during antenatal visits from 1 January 2009 to 30 June 2015. The 100g OGTT results following either one-step or two-step approach were interpreted according to The Carpenter and Coustan’s modification of O’Sullivan and Mahan’s criteria. The participants were enrolled into case study and control groups with 1:2 ratio. All pregnant women with single abnormal value of the 100g OGTT were recruited into study group (n=395). Whereas, those with normal values for 100g OGTT (n=790) were randomly recruited into control group. Pregnancy outcomes were compared between the 2 groups.
Results : Women with single abnormal value 100g OGTT were older (31.82±4.92 vs. 30.79±5.58; p-value 0.001), had higher rate of family history of type 2 DM (36.5% vs. 30.8%; p-value 0.049) and lower mean gestational age at birth (38.07±1.55 vs. 38.32±1.38; p-value 0.005) than the control group. The adverse outcomes of pregnancy significantly occurred in the study group included higher rate of macrosomia (4.3% vs. 1.5%; p-value 0.003) and large for gestational age (LGA) (11.9% vs. 6.7%; p-value 0.002) when compared with the control group.
Conclusion : Women with single abnormal value of 100g OGTT, even not diagnosed with GDM, tend to experience adverse outcomes of pregnancy that obstetricians should be aware of.

Keywords : 100g OGTT, single abnormal value 100-gram glucose tolerance test, gestational diabetes mellitus, adverse outcomes of pregnancy

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