Clinical Characteristics and Treatment Response of Chronic
Inflammatory Demyelinating Polyradiculoneuropathy
Narupat Suanprasert MD*,
Suchat Hanchaiphiboolkul MD*
Affiliation :
* Department of Neurology, Prasat Neurological Institute, Bangkok, Thailand
Background : The incidence, prevalence, clinical phenotypes, and treatment response of chronic inflammatory demyelinating
polyradiculoneuropathy (CIDP) are varying in the world literature. There have been no epidemiologic studies of CIDP in
Thai adult patients.
Objective : To determine clinical characteristics, phenotypes, electrophysiological tests, and treatment response of CIDP in
Thai adult patients and to find factors associated with disease outcome after treatment.
Material and Method: Retrospective chart review of Prasat Neurological Institute patients diagnosed of CIDP between
January 1, 2008 and December 31, 2014.
Results : Sixty-three CIDP patients were identified. Patients were slightly male predominant (1.3:1), age at onset was 47.7
years, disease duration prior to first evaluation was 5.0 months, follow-up duration was 26.8 months, and 19% of patients
had diabetes. Clinical phenotypes were classic CIDP (76.2%), 19% DADS, and 4.8% MADSAM. Fifteen point nine percent
presented as AIDP and 12.7% as SIDP. Symmetrical, sensorimotor polyneuropathy with hyporeflexia were the common
presentation. Autonomic symptoms, respiratory failure, bulbar involvement, ophthalmoparesis, ptosis, and muscle atrophy
were rarely presented. The treatment response was generally favorable. Patients in disease relapsing group had shorter
disease onset (2 vs. 6 months) and 40% had disease duration less than four weeks.
Conclusion : Clinical characteristics, phenotypes, electrophysiological findings, and treatment response of CIPD in Thai
patients were not different from previously published studies in western and oriental populations. Mode of disease onset
may predict a response to immunosuppressive treatment in CIDP patients.
Keywords : Chronic inflammatory demyelinating polyradiculoneuropathy, CIDP, Thai patients, Treatment response
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