Efficacy and Safety in 1% Clotrimazole Powder,
Adjuvant Therapy in Patients with Superficial Fungal
Cutaneous Infection in Intertriginous Areas
Rasthawathana Desomchoke MD*, Sumanas Bunyaratavej MD*, Charussri Leeyaphan MD*,
Nuntida Prasertworonun MD*, Chuda Rujitharanawong MD*, Lalita Matthapan BSc*, Penvadee Pattanaprichakul MD*
Affiliation :
* Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand
Background : Superficial fungal cutaneous infection is commonly found in intertriginous area.
Objective : To assess 1% clotrimazole powder (1% CP) efficacy for adjuvant treatment of superficial fungal cutaneous
infection in intertriginous areas.
Material and Method: The study performed as an open-label, randomized, comparative study for evaluating the effects of
1% clotrimazole cream (1% CC) with 1% CP in patients infected with dermatophytes (DMPs) or Candida spp. in intertriginous
area, comparing to patients treated with 1% CC as control by demonstrating complete cure rate at 4, 8, and 12 weeks as
well as relapse rates during a 24-week period including patient satisfaction.
Results : Sixty-seven patients with mean age of 54.6 years were included in this study. Of those, 61.2% were males. Thirty-five
patients were infected with DMPs and 32 with Candida spp. The complete cure rates of experimental group were significantly
higher than the control group, as observed within four weeks (p = 0.01), especially for dermatophyte infection (p = 0.039).
Two cases had recurrent candidiasis in the control group. In both groups, relapse up to 24 weeks were not statistically
different. Additionally, there was no difference in patients’ satisfaction towards convenience of drug application.
Conclusion : Using of the 1% CP could be suggested as an adjuvant therapy and possibly preventive agent for superficial
fungal cutaneous infection in intertriginous areas.
Keywords : 1% clotrimazole powder, Dermatophytes, Candidiasis, Intertrigenious areas, Superficial fungal cutaneous
infection
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