Pinyo Rattanaumpawan MD, MSCE, PhD*,**, Thanyarak Wongkamhla MD**, Visanu Thamlikitkul MD*,**
Affiliation : * Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Objective : To determine the accuracy of International Statistical Classification of Disease and Related Health Problems, 
10th Revision (ICD-10) coding system in identifying comorbidities and infectious conditions using data from a Thai university 
hospital administrative database.
Material and Method: A retrospective cross-sectional study was conducted among patients hospitalized in six general 
medicine wards at Siriraj Hospital. ICD-10 code data was identified and retrieved directly from the hospital administrative 
database. Patient comorbidities were captured using the ICD-10 coding algorithm for the Charlson comorbidity index. 
Infectious  conditions  were  captured  using  the  groups  of  ICD-10  diagnostic  codes  that  were  carefully  prepared  by  two 
independent infectious disease specialists. Accuracy of ICD-10 codes combined with microbiological data for diagnosis of 
urinary tract infection (UTI) and bloodstream infection (BSI) was evaluated. Clinical data gathered from chart review was 
considered the gold standard in this study.
Results : Between February 1 and May 31, 2013, a chart review of 546 hospitalization records was conducted. The mean 
age of hospitalized patients was 62.8±17.8 years and 65.9% of patients were female. Median length of stay [range] was 
10.0 [1.0-353.0] days and hospital mortality was 21.8%. Conditions with ICD-10 codes that had good sensitivity (90% or 
higher) were diabetes mellitus and HIV infection. Conditions with ICD-10 codes that had good specificity (90% or higher) 
were cerebrovascular disease, chronic lung disease, diabetes mellitus, cancer, HIV infection, and all infectious conditions. 
By combining ICD-10 codes with microbiological results, sensitivity increased from 49.5 to 66% for UTI and from 78.3 to 
92.8% for BSI.
Conclusion :  The  ICD-10  coding  algorithm  is  reliable  only  in  some  selected  conditions,  including  underlying  diabetes 
mellitus and HIV infection. Combining microbiological results with ICD-10 codes increased sensitivity of ICD-10 codes 
for identifying BSI. Future research is needed to improve the accuracy of hospital administrative coding system in Thailand. 
Keywords : Comorbidities, ICD-10, Infectious conditions
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