Association of Peripheral Autonomic Neuropathy and
Sympathetic Skin Response in the Patients with Diabetic
Polyneuropathy: A Pilot Study in Thailand
Chinapat Gerawarapong MD*
Affiliation :
* Department of Rehabilitation Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand
Objective : Investigate the association of peripheral autonomic neuropathy (PAN) symptoms and sympathetic skin response
(SSR) in the patients with diabetic polyneuropathy (DPN) as a pilot study in Thai patients.
Material and Method: Sixty-eight DPN patients’ limbs, conducted retrospectively between June 2012 and January 2014,
were included and divided into two groups, 48 abnormal SSR limbs and 20 control limbs, respectively. All clinical data,
demographic characteristics, PAN symptoms, and other associated factors were compared and analyzed.
Results : A comparison between abnormal and normal SSR groups in DPN limbs showed no significant differences of age,
gender, body mass index (BMI), comorbidity of hypertension and dyslipidemia, duration of PAN symptoms, associated
neurological signs of impaired light touch sensation, and muscle weakness or atrophy (p-value >0.05). The PAN symptoms,
either anhidrosis or hypohidrosis, and hyporemia showed significantly correlated to abnormal SSRs (p-value = 0.003 and
0.028, respectively). Among symptoms of somatic small fiber neuropathy (SFN), burning paresthesia, and reduced thermal
sensation revealed significantly correlated to abnormal SSRs (p-value = 0.032 and 0.021, respectively). Moreover, the study
showed that history of fall in six months, history of foot ulcer in three months, impaired pinprick sensation, impaired
proprioceptive sensation, decreased deep tendon reflex, burning paresthesia, reduced thermal sensation, either anhidrosis
or hypohidrosis, and hyporemia had significantly associated with the occurrence of abnormal SSRs (p-value <0.05).
Conclusion : There was the association between PAN symptoms and abnormal SSRs in DPN patients’ limbs. These data
support the recent findings of several studies that abnormal SSR has the association with history of foot ulceration in diabetic
patients. It warrants further investigation into the clinical utility of the SSR in diabetic patients.
Keywords : Sympathetic skin response, Autonomic neuropathy, Peripheral neuropathy, Small fiber neuropathy, Diabetic mellitus
All Articles
Download