Isolated Ocular Relapse in Childhood Acute
Lymphoblastic Leukemia during Second Interim
Maintenance Phase of Chemotherapy: Case Report
Chalinee Monsereenusorn MD*, Piya Rujkijyanont MD*,
Worapot Srimanan MD**, Chanchai Traivaree MD, MSc*
Affiliation :
* Division of Pediatric Hematology/Oncology, Department of Pediatrics,
Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand
** Division of Pediatric Ophthalmology and Strabismus/Neuro-Ophthalmology, Department of Ophthalmology,
Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand
More than 80% of acute lymphoblastic leukemia (ALL) in pediatric population is curable by using combinations
of chemotherapy. However, 20% of the cases still suffer from disease relapse. The most common site of relapse is bone
marrow. Relapse of childhood ALL involving the eyeball is rare. However, it occurs in 2.2% of relapsing children. The
authors described a 10-year-old Thai boy with underlying ALL on therapy, presented with a one-month history of progressive
visual loss of his right eye. The clinical and imaging studies strongly suggested the diagnosis of isolated ocular relapse. In
this report, the authors presented the findings from successfully specific treatment consisting of systemic chemotherapy and
radiation therapy on the affected eye. From other studies, the outcome was more favorable in cases of ocular relapse off
therapy. In our study, one case of isolated ocular relapse ALL was reported.
Keywords : Acute lymphoblastic leukemia, Isolated ocular relapse, Children
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