The Expressions of P53, Bcl-2, and P-Glycoprotein
and Prognostic Impact in Patients with
Peripheral T-Cell Lymphoma (PTCL)
Jakrawadee Julamanee MD*,
Kanita Kayasut MD**, Arnuparp Lekhakula MD*
* Division of Clinical Hematology, Department of Internal Medicine, Faculty of Medicine,
Prince of Songkla University, Hat Yai, Songkhla, Thailand
** Division of Anatomical Pathology, Department of Pathology, Faculty of Medicine,
Prince of Songkla University, Hat Yai, Songkhla, Thailand
Affiliation :
Objective : To define the expressions of p53, Bcl-2, and p-glycoprotein and prognostic impact in patients with peripheral
T-cell lymphoma (PTCL).
Material and Method: Adult patients with newly diagnosed as PTCL were reviewed from 2001 to 2012. Clinical parameters
and outcome data were extracted. The specimens were stained for p53, Bcl-2, and p-glycoprotein. The results were analyzed
for association with disease stage, International Prognostic Index (IPI), Prognostic Index for T-cell lymphoma (PIT), overall
response rate (ORR), and overall survival (OS).
Results : Of eligible 159 patients (113 males, 46 females), median age was 53 years old. The histological subtypes included
peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) 35.8%, angioimmunoblastic T-cell lymphoma (AITL)
18.2%, extranodal NK/T-cell lymphoma (ENKL) 17.0%, subcutaneous panniculitis-like T-cell lymphoma (SPTCL) 12.6%,
cutaneous T-cell lymphoma (CTCL) 11.3%, anaplastic large cell lymphoma (ALCL) 4.4%, and enteropathy-associated T-cell
lymphoma (EATL) 0.6%. Tissue samples were obtained for analysis in 135 patients. P53, Bcl-2, and p-glycoprotein were
positive in 87%, 49%, and 28%, respectively. Median OS was 25 months. The expressions of p53, Bcl-2, and p-glycoprotein
were not significantly correlated with advanced stage, high prognostic scores, ORR, and OS. However, Bcl-2 expression
was statistically associated with histological subtypes. From Cox regression analyses, advanced stage, high prognostic
scores, and histological subtypes were independent prognostic factors for OS.
Conclusion : The biomarker expressions varied in different types of PTCL and did not show any correlation with prognostic
factors, ORR, or OS.
Keywords : P53, Bcl-2, P-glycoprotein, Peripheral T-cell lymphoma, Prognosis
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