The Changes in Mean Platelet Volume after Using of
Antiplatelet Drugs in Acute Ischemic Stroke:
A Randomized Controlled Trial
Rojanant Haungsaithong MD*,
Chesda Udommongkol MD, PhD*, Samart Nidhinandana MD*, Parnsiri Chairungsaris MD*,
Yotin Chinvarun MD, PhD*, Jithanorm Suwantamee MD*, Pasiri Sithinamsuwan MD*
Affiliation :
* Division of Neurology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand
Objective : To measure the changes of mean platelet volume (MPV) after using four antiplatelet drugs in acute
non-cardioembolic ischemic stroke patients and assess the association of antiplatelets and MPV and stroke outcome.
Material and Method: Ischemic stroke survivors with National Institute of Health Stroke Scale (NIHSS) ≤8 were randomly
allocated into four groups, receiving aspirin, clopidogrel, combined aspirin and dipyridamole, and cilostazol. The change
of MPV, NIHSS, and modified Rankin Scale (mRS) were recorded at baseline and week 4 in all studied groups. MPV was
measured using the standard automated blood test for complete blood count.
Results : Twenty-one subjects were included in this study. They comprised of five cases in each antiplatelet group, except
for aspirin, which had six subjects. Male was 57%, and hypertension was the most common risk factor (61.9%). Most of
participants (76%) had small vessel disease. At 4-week, MPV was reduced and NIHSS, mRS were improved in every studied
group. Clopidogrel significantly reduced NIHSS score (p = 0.003), and it produced the greatest reduction in MPV compared
to others.
Conclusion : Every type of antiplatelets included in this study reduced MPV, NIHSS, and mRS in acute non-cardioembolic
stroke patients. Clopidogrel improved NIHSS the most.
Keywords : Mean platelet volume (MPV), Stroke, Antiplatelet drugs
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