The Factors Associated with Mild Cognitive Impairment
(MCI) in Surgical Menopause Women
Malika Kengsakul MD*, Sukanya Chaikittisilpa MD*,
Solaphat Hemrungrojn MD**, Krasean Panyakhamlerd MD*,
Unnop Jaisamrarn MD, MHS*, Nimit Taechakraichana MD*
Affiliation :
* Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
** Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Background and
Objective : As a sizeable proportion of persons with mild cognitive impairment will progress to frank
dementia, early detection is an important strategy to prevent and decelerate the progression of cognitive decline. In Thailand,
the prevalence of mild cognitive impairment in surgical menopause women has not been well established. The objectives
of the present study were to determine the percentage and factors associated with mild cognitive impairment in women with
surgical menopause.
Material and Method: Between October 2013 and July 2014, 200 eligible women at King Chulalongkorn Memorial Hospital
were enrolled. The self-reported questionnaires were used to obtain the demographic data and the Thai version of the
Montreal Cognitive Assessment (MoCA) was used to detect mild cognitive impairment (MCI). The MCI was diagnosed
when the MoCA score was less than 25. The data were statistically analyzed using SPSS version 17 for student t-test, Chi-
square test, and multiple regression analysis.
Results : The percentage of MCI in the present study was 43.5%. The univariate analysis showed that factors significantly
related to MCI were marital status, educational levels, occupation, monthly income, and duration of hormone replacement
therapy (HRT). Nevertheless, multiple regression analysis revealed that only older age at enrollment, marital status, low
educational level, and low monthly income were significantly related to MCI.
Conclusion : Almost half of the surgical menopause women in the present study had MCI. Older age at enrollment, marital
status, low educational level, and low monthly income were significantly related to MCI. Age at surgical menopause and
HRT were not found to be associated with MCI in this study.
Keywords : Mild cognitive impairment (MCI), Surgical menopause
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