Relationship between Cardio-Ankle Vascular Index (CAVI) and Obstructive Sleep Apnea (OSA)

Sasithon Romsaiyut MD*, Wattanachai Chotnaiyawattrakul MD**, Thananya Boonyasirinant MD***

Affiliation : * Department of Internal Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Division of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand *** Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Background and
Objective : A non-invasive test called Cardio-Ankle Vascular Index (CAVI) measures aortic stiffness, which is an early sign of atherosclerosis. Obstructive sleep apnea (OSA) has a close association with cardiovascular mortality and morbidity. We sought to assess the relationship between OSA and arterial stiffness. Material and Method: Seventy-one patients with OSA (apnea-hypopnea index AHI ≥5, mean age 51.514.1 years, 27 females) and 11 controls (AHI <5, mean age 56.811.8 years, 5 females) were enrolled in the study. In all subjects, arterial stiffness (CAVI) was performed and recorded along with blood pressure, pulse pressure of brachial arteries, and ankle arteries.
Results : The demographic data of the patients with OSA and controls were not significantly different. Subjects with OSA demonstrated higher values of mean ankle artery pulse pressure than the controls (73.114.6 vs. 59.66.1 mmHg, respectively), but arterial stiffness and CAVI had no statistically significant difference (7.471.68 vs. 7.251.61, respectively).
Conclusion : There was no relationship between arterial stiffness CAVI, and the presence of OSA. However, there was a significant association between ankle artery pulse pressure and the presence of OSA.

Keywords : CAVI, OSA, Pulse pressure

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