Comparative Study between the Phramongkutklao’s
Diabetic Blenderized Diets and Commercial Diabetic
Diets on Glycemic Variability in Continuous
Tube Fed Patients with Type 2 Diabetes
Teeranun Tiyapanjanit MD*,
Apussanee Boonyavarakul MD*
Affiliation :
* Division of Endocrinology and Metabolism, Department of Medicine, Phramongkutklao Hospital and College of Medicine,
Bangkok, Thailand
Background : Rapid glucose fluctuations over daily period play an important role on diabetic complications.
Objective : To compare glycemic variability, mean plasma glucose, number of capillary blood glucose tests, and cost between
the Phramongkutklao’s diabetic formula and commercial diabetic formula in continuous tube fed patients with stable
condition in type 2 diabetes.
Material and Method: A cross-over design study was performed between October 2010 and February 2011 in the medical
department in Phramongkutklao Hospital. The researchers enrolled type 2 diabetic patients with stable condition who were
on continuous tube fed. Seventy-two-hour continuous subcutaneous glucose monitoring was performed in all patients.
Comparison of mean amplitude of glycemic excursions (MAGE), mean plasma glucose, cost, and number of capillary blood
glucose tests were analyzed by using non-parametric Wilcoxon signed-rank test. Significance was defined as p<0.05.
Results : Ten subjects were included in the present study. The Phramongkutklao’s Diabetic Formula resulted in significantly
lower mean plasma glucose (12226.25 vs. 144.6836.91 mg/dL, p = 0.022), cost (550.133.57 vs. 797.8142.29 baht,
p = 0.004), and number of capillary blood glucose tests (50.94 vs. 5.30.82 times, p = 0.083) when compared with
commercial diabetic formula, but no significant difference in MAGE level (5.862.78 vs. 7.714.34 mg/dL, p = 0.333).
Conclusion : The Phramongkutklao’s diabetic formula has significantly lower mean plasma glucose, less number of capillary
blood glucose tests, and is less expensive than commercial diabetic formula. The glucose variability (MAGE) of the
Phramongkutklao diabetic formula has also less than commercial diabetic formula, but does not reach statistical significance.
The level of plasma glucose was lower than 180 mg/dL in both formulas.
Keywords : Glycemic variability, Diabetic formula, Type 2 diabetes
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