Elective Cesarean Delivery as a Predisposing Factor of
Respiratory Syncytial Virus Bronchiolitis in Children
Xiaoli Shang MD*, Tippawan Liabsuetrakul MD, PhD**,
Pasuree Sangsupawanich MD, PhD***, Xiaoling Xia MD*,
Ping He MD****, Hong Cao MD*****
Affiliation :
* Department of Pediatrics, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
** Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
*** Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
**** Department of Pediatrics, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, Yunnan, China
***** Department of Pediatrics, Yan’an Hospital of Kunming City, Kunming, Yunnan, China
Objective : To investigate the effect of cesarean delivery and other predisposing factors of respiratory syncytial virus
(RSV)-positive acute bronchiolitis in children.
Material and Method: The case-control study was conducted in three main tertiary hospitals in Kunming, China between
September 2012 and July 2013. Children with first episode of wheezing diagnosed as bronchiolitis and tested for RSV were
included. RSV was detected by real-time reverse transcription polymerase chain reaction. Mode of delivery and characteristics
of children, parents, and household were interviewed and analyzed with RSV-positive status by multiple logistic regression.
Results : Of 265 children, RSV-positive was found in 75.5%, and the majority of children (83.3%) were younger than
12 months. Compared to vaginal delivery, the odds of RSV-positive detection were double in children born by elective
cesarean delivery (adjusted odds ratio 2.32; 95% confidence interval 1.19-4.52). Children aged less than 6 months, born
in the rainy season, having maternal history of asthma and living in family that smoked more than 20 cigarettes per day
were more likely to be RSV-positive.
Conclusion : Children born by elective cesarean delivery increased the risk of RSV-positive acute bronchiolitis after adjusting
for age, birth season, maternal asthma, and family smoking status.
Keywords : Acute bronchiolitis, Elective cesarean delivery, Predisposing factor, Respiratory syncytial virus
All Articles
Download