Comparative Trial of Moisturizer Containing Spent
Grain Wax, Butyrospermum parkii Extract, Argania
spinosa Kernel Oil vs. 1% Hydrocortisone Cream in
the Treatment of Childhood Atopic Dermatitis
Panaya Jirabundansuk MD*,
Suwirakorn Ophaswongse MD*, Montree Udompataikul MD*
Affiliation :
* Skin Center, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand
Objective : To compare an efficacy of a moisturizer containing spent grain wax, Butyrospermum parkii extract, Argania
spinosa kernel oil (S) with 1% hydrocortisone cream (HC) for the treatment of mild to moderate atopic dermatitis.
Material and Method: Twenty-nine patients, age between 2 and 15 years old with mild to moderate atopic dermatitis were
enrolled. The body was randomly divided to left and right side. One side was applied with S cream and the other side was
applied with HC cream twice daily for four weeks. Observation of recurrence rate after remission was recorded. Clinical
outcomes were analyzed by using the scoring of Atopic Dermatitis (SCORAD) score. Statistical analysis was done by using
descriptive statistics, pair t-test, one-way repeated ANOVA, and McNemar’s test.
Results : It was demonstrated that both agents had improvement of SCORAD score after two weeks, with statistically
significant difference (p<0.001). At fourth week, both agents had improvement of SCORAD score without being statistically
significant different (p>0.05). Although the S cream side had higher remission rate than the HC cream side, there was no
statistically significant difference (p>0.05).
Conclusion : S cream was as effective as HC cream in the treatment and maintenance period of mild to moderate childhood
atopic dermatitis.
Keywords : Atopic dermatitis, Childhood, Hydrocortisone, Spent grain wax, Butyrospermum parkii (shea butter) extract,
Argania spinosa kernel oils
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